A: representative experimental records, illustrating the characteristic features of pressure changes and the audio signal generated by a single cough (cough reflex, CR; left) and a single expiration reflex (ER; right). B: additional experimental records (from left to right): a CR (solid arrowhead), an ER (open arrowhead), a cough epoch consisting of a combination of CR and ER, and a cough epoch of CR/ER and ER. CR/ER (asterisk) depicts the cough response that could not be distinguished between CR and ER. Pcham, pressure inside the chamber; Pip, intrapleural pressure recorded via the telemetry sensor in awake mice.