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. 2017 Mar 10;312(5):H919–H931. doi: 10.1152/ajpheart.00425.2016

Fig. 4.

Fig. 4.

Effects of β-AR stimulation and inhibition on cAMP production in E11.5 ventricular cells. Basal cAMP levels in untreated cells were set to a value of 1.0 and data represent fold changes in cAMP in response to ISO with or without β-AR antagonists. A: stimulation of E11.5 ventricular cells with 1 µM ISO was associated with an approximate fourfold increase in cAMP. Cotreatment of cells with ISO and metoprolol (Meto) abolished the increase in cAMP production observed with ISO alone. B: cotreatment of E11.5 cells with ISO and ICI-118,551 (ICI) also abolished the increase in cAMP production observed with ISO alone. *P < 0.05 vs. basal; #P < 0.05 vs. ISO alone, one-way ANOVA, Tukey’s multiple-comparisons test. Each bar represents means ± SE; n = 3–5 independent experiments.