Fig. 8.

Effects of ANG II on superoxide levels in human adipose microvascular endothelial cells (HAMECs). In HAMECs, treatment with ANG II (400 nM) evoked a significant increase in ${\mathrm{O}}_{\mathrm{2}}^{\mathrm{-}}$ levels. *P < 0.05. Combined treatment with ANG II + losartan (AT₁R blocker), VAS2870 or NSC23766 (NOX II inhibitors), or tiron (SOD mimetic) significantly reduced the ANG II-induced increase in ${\mathrm{O}}_{\mathrm{2}}^{\mathrm{-}}$ in HAMECS. †P < 0.05. Data are presented as means ± SE.