Table 1.

Characteristics of 79 ALTA subjects who underwent mBAL

Parameter	Value
Age, yr	49 ± 16
Male sex	45 (57)
Race
White	50 (63)
Black	13 (16)
Asian	4 (5)
Unknown or other	12 (15)
Latino ethnicity	6 (8)
Primary etiology of lung injury
Pneumonia	32 (41)
Sepsis	18 (23)
Aspiration	17 (22)
Trauma	6 (8)
Unknown or other	6 (8)
APACHE III score	86 (22)
Albuterol intervention arm	42 (53)
Vasopressor use	33 (42)
Serum protein, g/dl‡	5.2 (1.3)
mBAL total protein, µg/ml	1,793 (948–3221)
mBAL IgM, ng/ml	413 (335–502)
IL-6, pg/ml	259 (59–926)
IL-8, pg/ml	74 (38–168)
Mean airway pressure, cmH2O	14 (11–16)
Oxygenation Index†	7 (4–10)
$\mathrm{P}{\mathrm{a}}_{\mathrm{O}}{}_{{}_{\mathrm{2}}}$/$\mathrm{F}{\mathrm{I}}_{{\mathrm{O}}_{\mathrm{2}}}$†‡	190 (154–260)
Driving pressure†‡	13 (11–16)
Ventilator-free days*	21 (0–25)
Hospital days*	19.5 (13–28)
ICU days*	13 (9–22)
Mortality at 28 days	15 (19)

All data are presented as means ± SD, median (IQR), or n (%) as appropriate. ALTA, Aerosolized Albuterol Versus Placebo in Acute Lung Injury ARDS Network trial. APACHE, Acute Physiology and Chronic Health Evaluation; mBAL, mini-bronchoalveolar lavage; ICU, intensive care unit.

$\text{Oxygenation index}=\frac{(\text{mean airway pressure})\times (\text{fraction of inspired oxygen})}{(\text{partial pressure of arterial oxygen})}$ $\mathrm{P}{\mathrm{a}}_{\mathrm{O}}{}_{{}_{\mathrm{2}}}$/$\mathrm{F}{\mathrm{I}}_{{\mathrm{O}}_{\mathrm{2}}}$, partial pressure of arterial oxygen:fraction of the inspired oxygen. Driving pressure = plateau pressure − peak end expiratory pressure.

^*To 28 days.

^†Variable measured when subject on study protocol; see materials and methods.

^‡Missing data: Serum protein, n = 16 (20%); oxygenation index and driving pressure, n = 8 (10%).