Fig. 6.

Effects of nicotine on phosphorylation of Akt, Erk, and p38-MAPK. A: nicotine treatment for 30 min does not change Akt or Erk phosphorylation but does acutely decrease phosphorylated p38-MAPK. Representative blots are shown. B: quantitation of the ratio of p-p38 to total p38 and total p38 to the loading control vinculin from A. Data are normalized to Veh. C: reduced p38-MAPK phosphorylation is blocked by the nAChR antagonist Mec. A representative blot is shown, n = 5. *P < 0.05 vs. vehicle, unpaired t-test.