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. 2017 Mar 22;215(9):1396–1406. doi: 10.1093/infdis/jix138

Figure 2.

Figure 2.

Administration of 2-deoxy-d-glucose (2-DG) attenuates sepsis-induced organ injury and improves survival outcome. Mice were treated with 2-DG (0.25 g/kg body weight) 3 hours before induction of cecal ligation and puncture (CLP) sepsis. Serum levels of aspartate aminotransferase (AST; A), creatinine (B), and creatine kinase (C) were measured by commercially available enzyme-linked immunosorbent assay kits. D–F, 2-DG administration improves survival outcome. Mice were treated with 2-DG (2 g/kg body weight [D] or 0.25 g/kg body weight [E]) 3 hours prior to CLP and were then re-treated with 2-DG (500 mg/kg) 24 hours after CLP. D and E, Acute CLP sepsis. F, Chronic CLP septic mice treated with 2-DG at 0.5 kg/kg body weight 3 hours prior to CLP. The animals were monitored for lethality every 2 hours for up to 250 hours following CLP. n = 10–18/group. *P < .05, **P < .01, and ***P < .001 compared with indicated groups.