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. 2017 Mar 22;215(9):1396–1406. doi: 10.1093/infdis/jix138

Figure 6.

Figure 6.

Administration of 2-deoxy-d-glucose (2-DG) attenuated sepsis-induced decreases in the levels of nicotinamide adenine dinucleotide (NAD+, oxidized form), Sirt1, and Sirt3 in the myocardium. Hearts were harvested 8 hours after cecal ligation and puncture (CLP) for preparation of cellular proteins. NAD+ (A) and nicotinamide adenine dinucleotide (NADH, reduced form) (B) levels were examined by commercially available kits. C, Ratio of NAD+/NADH. D and E, 2-DG treatment increased the levels of Sirt1 (D) and Sirt3 (E) in the myocardium. F and G, 2-DG treatment prevents MKK3 phosphorylation and expression in the myocardium. n = 4–6/group. *P < .05, **P < .01, and ***P < .001 compared with indicated groups.