Table 2. Experimental studies on the improvement of the microcirculation in the liver.

Author	Drug	Animal model	Results/effect on perfusion
Ferguson et al. (33)	5 mg/kg dexamethasone	Dog	Mean arterial blood pressure↑
			Lung, kidney, stomach and intestinal blood flow↑
			Cell damage↓
Waxman et al. (34)	25 mg/kg pentoxifylline	Rat	Oxygen tension liver surface↑
Marzi et al. (35)	25 mg/kg pentoxifylline or albifylline	Rat	Hepatic micro-circulation↑
			Leukocyte adhesion to the vascular endothelium↓
Shimizu et al. (36)	1 mg/kg dehydroepiandrosteron	Rat	Cardiovascular function in ♂↑
			Liver function in ♂↑
Schmidt et al. (37)	1.5 mg/kg dihydralazine	Rat	Microvascular hepatic circulation↑
			Liver injury↓
Mathes et al. (38)	10 mg/kg melatonin	Rat	Liver perfusion↑
			Hepatocellular injury↓
Kubulus et al. (39)	5 mg/kg hemin arginate	Rat	Hepatic micro-circulation↑
			Inflammation↓
Kubulus et al. (40)	Bosentan 10 mg/kg	Rat	Liver perfusion↑
			Hepatocellular injury↓
			Cytokines↓
Mahmoud et al. (41)	Infliximab or pentoxifylline (50 mg/kg)	Rat	Oxidative stress markers↓
			TNF-α↓
			NF-α type-1 receptors↓
			NF-κB↓
Liu et al. (42)	Sirtinol (1 mg/kg)	Rat	Hepatic myeloperoxidase activity↓
			ICAM-1↓
			IL-6 levels↓
			Liver injury↓
Yamada et al. (43)	333  ìg/kg · h; Pep19-4LF	Rat	Arterial pressure↑
			Liver injury↓
			TNF-α↓
Müller-Redetzky et al. (44)	0.05 mg/kg · h; adrenomedullin	Mouse	Apoptosis in liver cells↓
			Apoptosis in gut cells↓