Table 4.
Empiric Antimicrobial Agents Stratified by Site of Infection
| Number (%) of Patients | |||||
|---|---|---|---|---|---|
| Empiric Antimicrobial Therapy | Infection Type | ||||
| Bacteremia (N = 140) | HABP (N = 21) | VABP (N = 20) | cUTI (N = 75) | All (N = 256) | |
| n (%) | n (%) | n (%) | n (%) | n (%) | |
| No treatment | 8 (5.7%) | 2 (9.5%) | 0 | 18 (24.0%) | 28 (10.9%) |
| No Gram-negative coverage | 1 (0.7%) | 0 | 1 (5.0%) | 1 (1.3%) | 3 (1.2%) |
| Gram-negative therapy | 131 (93.6%) | 19 (90.5%) | 19 (95.0%) | 56 (74.7%) | 225 (87.9) |
| Monotherapy | 72 (51.4%) | 15 (71.4%) | 14 (70.0%) | 47 (62.7%) | 148 (57.8) |
| All combination therapy | 59 (42.1%) | 4 (19.0%) | 5 (25.0%) | 9 (12.0%) | 77 (30.1%) |
| Dual therapy | 38 (27.1%) | 1 (4.8%) | 3 (15.0%) | 7 (9.3%) | 49 (19.1%) |
| 3-drug combinations | 19 (13.6%) | 1 (4.8%) | 2 (10.0%) | 1 (1.3%) | 23 (9.0%) |
| 4 and more drug combinations | 2 (1.4%) | 2 (9.5%) | 0 | 1 (1.3%) | 5 (2.0%) |
| Number Active Agents | |||||
| No active agent | 71 (50.7%) | 15 (71.4%) | 15 (75.0%) | 41 (54.7%) | 142 (55.5%) |
| One active agent | 48 (34.3%) | 3 (14.3%) | 4 (20%) | 15 (20.0%) | 70 (27.3%) |
| Two active agentsa | 12 (8.6%) | 1 (4.8%) | 0 | 0 | 13 (5.1%) |
Abbreviations: cUTI, complicated urinary tract infection; HABP, hospital-acquired bacterial pneumonia; VABP, ventilator-associated bacterial pneumonia.
aNo subjects received empiric antimicrobial therapy with more than 2 agents with antimicrobial activity against the index CRE pathogen.