Table 5.
Directed Antimicrobial Agents Stratified by Site of Infection
| Number (%) of Patients | |||||
|---|---|---|---|---|---|
| Directed Antimicrobial Therapy | Infection Type | ||||
| Bacteremia (N = 140) | HABP (N = 21) | VABP (N = 20) | cUTI (N = 75) | All (N = 256) | |
| n (%) | n (%) | n (%) | n (%) | n (%) | |
| No treatment | 15 (10.7%) | 3 (14.3%) | 1 (5.0%) | 21 (28.0%) | 40 (15.6%) |
| No Gram-negative coverage | 0 | 1 (4.8%) | 1 (5.0%) | 0 | 2 (0.8%) |
| Gram-negative therapy | 125 (89.3%) | 17 (81.0%) | 18 (90.0%) | 54 (72.0%) | 214 (83.6%) |
| Monotherapy | 33 (23.6%) | 6 (28.6%) | 3 (15.0%) | 38 (50.7%) | 80 (31.3%) |
| All combination therapy | 92 (65.7%) | 11 (52.4%) | 15 (75.0%) | 16 (21.3%) | 134 (52.3%) |
| Dual therapy | 40 (28.6%) | 6 (28.6%) | 5 (25.0%) | 6 (8.0%) | 57 (22.3%) |
| 3-drug combinations | 42 (30.0%) | 4 (19.0%) | 9 (45.05) | 8 (10.7%) | 63 (24.6%) |
| 4 and more drug combinations | 10 (7.1%) | 1 (4.8%) | 1 (5.0%) | 2 (2.7%) | 14 (5.5%) |
| Number Active Agents | |||||
| No active agent | 18 (12.9%) | 3 (14.3%) | 4 (20.0%) | 21 (28.0%) | 46 (18.0%) |
| One active agent | 70 (50.0%) | 7 (33.3%) | 8 (40.0%) | 30 (40.0%) | 115 (44.9%) |
| Two or more active agents | 37 (26.4%) | 7 (33.3%) | 6 (30.0%) | 3 (4.0%) | 53 (20.7%) |
| Two active agents | 33 (23.6%) | 7 (33.3%) | 5 (25.0%) | 3 (4.0%) | 48 (18.8%) |
| Three active agents | 3 (2.1%) | 0 | 1 (5.0%) | 0 | 4 (1.6%) |
| Four or more active agents | 1 (0.7%) | 0 | 0 | 0 | 1 (0.7%) |
Abbreviations: cUTI, complicated urinary tract infection; HABP, hospital-acquired bacterial pneumonia; VABP, ventilator-associated bacterial pneumonia.