Table 7.
Outcomes of Infections Due to Carbapenem-Resistant Enterobacteriaceae Within Specific Subgroups
| Subgroup | Number, (%)a of Patients | ||||||
|---|---|---|---|---|---|---|---|
| 28-Day Mortality n (%) | Clinical Cureb n (%) | Total in Subgroup | |||||
| Yes | No | Unknown | Yes | No | Unknown | n/N (%)c | |
| Chronic renal insufficiencyd | 28 (33.3%) | 49 (58.3%) | 7 (8.3%) | 41 (48.8%) | 41 (48.8%) | 2 (2.4%) | 84 (32.8%) |
| Requirement for dialysis | 21 (41.2%) | 26 (51.0%) | 4 (7.8%) | 18 (35.3%) | 30 (58.8%) | 3 (5.9%) | 51 (19.8%) |
| Immunocompromised conditione | 21 (31.3%) | 41 (61.2%) | 5 (7.5%) | 34 (50.7) | 33 (49.3%) | 0 (0.0%) | 67 (26.2%) |
| Presentation with severe sepsisf | 37 (44.0%) | 40 (47.6%) | 7 (8.3%) | 37 (44.0%) | 45 (53.6%) | 2 (2.4%) | 84 (32.8%) |
| Presentation with septic shockg | 35 (46.7%) | 35 (46.7%) | 5 (6.7%) | 31 (41.3%) | 42 (56.0%) | 2 (2.7%) | 75 (29.3%) |
Abbreviations: DIC, disseminated intravascular coagulation; SBP, systolic blood pressure.
an represents the number of patients in each subgroup who met the respective endpoint. The percentage (%) of subjects in that subgroup who met that endpoint is denoted below the value for n (eg, 28 subjects with chronic renal insufficiency died by day 28. This is 33.3% of the total number of subjects with chronic renal insufficiency).
bClinical cure as ascertained by study investigator.
cn represents the number and percentage (%) of patients with each condition within the total study population (N= 256).
dChronic renal insufficiency was defined as moderate-to-severe renal disease.
eImmunocompromised condition included hematologic malignancy, prior bone marrow transplant, or received immunosuppressive therapy, such as cancer chemotherapy, antirejection medications for transplantation, or long-term (≥2 weeks) use of systemic steroids.
fSevere sepsis was defined as infection associated with any of the following: hypotension (SBP ≤90 mmHg or a decrease in SBP of ≥40 mmHg from baseline [if known] unresponsive to fluid challenge), hypothermia (core temperature <35.6°C or <96.1°F), or DIC as evidenced by prothrombin time or partial thromboplastin time 2× the upper limit of normal or platelets less than 50% of the lower limit of normal [13].
gSeptic shock (a subset of severe sepsis) was defined as infection associated with hypotension (SBP ≤90 mmHg or a decrease in SBP of ≥40 mmHg from baseline [if known] unresponsive to fluid challenge) [13].