Figure 2. Effects of APJ agonist and antagonist microinjection into the RVLM on blood pressure and heart rate.

A, raw BP and HR traces showing representative responses following the bilateral microinjection of [Pyr¹]apelin‐13 (200 pmol 100 nl side⁻¹) before and after the injection of the APJ antagonist F13A (2 nmol 100 nl side⁻¹). Arrows mark the bilateral injection of [Pyr¹]apelin‐13. B and C, changes in MABP (B) and HR (C) following bilateral microinjection of saline vehicle control and [Pyr¹]apelin‐13 before (white bars) and after (black bars) administration of F13A. B and C, data are shown as the mean ± SEM (n = 6). ^** P < 0.01, ^*** P < 0.001. Scale bars for BP, HR and time are indicated.