Figure 4. Cardiovascular effects of [Pyr¹]apelin‐13 in the RVLM after blockade of VP V1a receptors.

A, raw BP and HR traces showing representative responses following the bilateral microinjection of VP (50 pmol 100 nl side⁻¹) and [Pyr¹]apelin‐13 (200 pmol 100 nl side⁻¹) before and after the injection of the VP V1a receptor antagonist, SR 49059 (200 pmol 100 nl side⁻¹). Arrows mark the times of bilateral injections. B and C, changes in MABP (B) and HR (C) following bilateral microinjection of saline vehicle control, [Pyr¹]apelin‐13 and VP before (white bars) and after (black bars) administration of SR 49059. B and C, data are shown as the mean ± SEM (n = 6). ^** P < 0.01, ^*** P < 0.001. Scale bars for BP, HR and time are indicated.