Figure 5. Effect of RVLM oxytocin receptor antagonist microinjection on [Pyr¹]apelin‐13‐induced cardiovascular responses.

A, raw BP and HR traces showing representative responses following the bilateral microinjection of OT (50 pmol 100 nl side⁻¹) and [Pyr¹]apelin‐13 (200 pmol 100 nl side⁻¹) before and after the injection of the OT receptor antagonist, dOVT (200 pmol 100 nl side⁻¹). Arrows mark the times of bilateral injections. B and C, changes in MABP (B) and HR (C) following bilateral microinjection of saline vehicle control, [Pyr¹]apelin‐13 and OT before (white bars) and after (black bars) administration of dOVT. B and C, data are shown as the mean ± SEM (n = 6). ^* P < 0.05, ^*** P < 0.001. Scale bars for BP, HR and time are indicated.