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. 2017 Mar 10;595(11):3573–3590. doi: 10.1113/JP274059

Figure 4. Maturation of excitatory postsynaptic inputs is impaired in VNLL neurons of nicotine‐treated mice.

Figure 4

A, EPSC amplitudes as a function of stimulus number for untreated (ctr) and nicotine‐treated (nic) VNLL neurons of P8 and P22 mice. B–D, the total maximal EPSC amplitude (B), the minimal EPSC amplitude (C) and the estimated number of excitatory input fibres (D) are shown for ctr and nic VNLL neurons of P8, P14 and P22 mice. P8, ctr n = 8, nic n = 13; P14, ctr n = 7, nic n = 11; P22, ctr n = 15, nic n = 19. E and F, rise time 10–90% (E) and tau decay (F) of the average EPSC evoked by minimal stimulation for ctr and nic VNLL neurons of P8, P14 and P22 mice. P8, ctr n = 10, nic n = 13; P14, ctr n = 8, nic n = 11; P22, ctr n = 17, nic n = 19. At P8 there are no differences between ctr and nic VNLL neurons while developmental remodelling of excitatory inputs is delayed in nic mice. * P < 0.05, Students unpaired t test for parametric distributions and Mann‐Whitney U test for non‐parametric distributions.