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. 2017 Apr 23;595(11):3535–3547. doi: 10.1113/JP273005

Figure 5. DCS post adaptation modulates synaptic efficacy and is driven by recruitment of afferent axons.

Figure 5

A, cathodal (blue) and anodal DCS (magenta) during a train of synaptic inputs at 10 Hz modulates synaptic efficacy for the duration of the electric field (EF) despite adaptation. B, DCS polarity specifically modulates the first field potential (FP) amplitude relative to pre‐DCS. C, there is a correlation between the change in the first FP amplitude and the amount of recovery from facilitation or depression during DCS. D, changing the stimulus intensity, instead of applying DCS, results in similar dynamics on FP amplitude. Decreasing stimulus intensity by a half (left) decreases FP amplitudes. There is a pronounced rebound in FP amplitude when the stimulus intensity is returned to the probe intensity. E, a simple dynamic synapse model incorporating recruitment of presynaptic inputs is able to reproduce the effects of DCS on synaptic efficacy and the post‐DCS rebound effect. [Color figure can be viewed at wileyonlinelibrary.com]