Figure 6. DCS modulates synaptic efficacy post adaptation through somatic polarization alone.

A, schematic diagram of orthodromic stimulation of L2/3 during DCS. Current flow along the somato‐dendritic axis and perpendicular to the horizontally oriented axons selectively polarizes the postsynaptic cells and not the axons. B, current flow along the somato‐dendritic axis during orthodromic stimulation of the horizontal L2/3 pathway modulates synaptic efficacy independently of axonal recruitment. C, anodal DCS facilitates synaptic efficacy and cathodal DCS depresses efficacy. [Color figure can be viewed at wileyonlinelibrary.com]