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The autopsy findings. (A) The cut surface of the liver demonstrated innumerable 2–4 mm cream colored, soft nodules; (B) On histopathology, these proved to represent foci of geographic necrosis, highlighted here with an HSV immunostain; (C) High power photomicrograph demonstrates two hepatocytes with typical HSV cytopathic effect (arrows) characterized by multinucleation, margination (i.e., peripheral displacement) of chromatin, and ground-glass nuclei.
