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. 2017 May 24;4(5):170014. doi: 10.1098/rsos.170014

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© 2017 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 1. — A three-compartment model of drug distribution in tissue. C₁ represents extracellular drug concentration, C₂ is free intracellular drug concentration and C₃ is bound intracellular drug concentration.