Figure 9.

Dependence of survival fraction on dosefor the two-dimensional cylindrically symmetric model where a cell is assumed to die if its exposure to bound drug exceeds 165 μM h: standard binding rate k₂, and unbinding rate k₋₂, from table 1 (a); much stronger binding and weaker unbinding (k₂=2.95×10⁻² μM⁻¹ s⁻¹ and $k_{-2}=4.38\times {10}^{-7}\hspace{0.17em}{\mathrm{s}}^{-1}$, b).