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Drug conversion of prodrug IV to β-lap in buffers at different
pH values. (a) Cumulative release of β-lap from prodrug IV at pH 5.0,
6.5 and 7.4; (b) Normalized HPLC trace of prodrug IV conversion at 1, 20, 40,
60, 120 and 360 mins at pH 5.0; (c) Conversion of prodrug IV to β-lap at
pH 5.0.