Scheme 1.
(a) Schematic illustration of pH sensitive β-Lap prodrug linkages. (b) Schematic representation to micelle two stage drug release. At physiological pH, drug conjugated polymers mPEG-b-P(DPA-r-PDSM(IV)) micelles keep stable. Whereas in pHs under pHt, at stage I, micelle immediately dissociation, and subsequently entering stage II, micelles quickly release payload drug β-lap.
