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. Author manuscript; available in PMC: 2017 Dec 14.
Published in final edited form as: J Mater Chem B. 2016 Oct 21;4(46):7429–7440. doi: 10.1039/C6TB02049F

Scheme 1.

Scheme 1

(a) Schematic illustration of pH sensitive β-Lap prodrug linkages. (b) Schematic representation to micelle two stage drug release. At physiological pH, drug conjugated polymers mPEG-b-P(DPA-r-PDSM(IV)) micelles keep stable. Whereas in pHs under pHt, at stage I, micelle immediately dissociation, and subsequently entering stage II, micelles quickly release payload drug β-lap.