Scheme 2.
Syntheses of β-lap prodrug analogues: (a) aceylhydrazide, TsOH; (b) 2-(hydroxymethyl)-2-methylpropane-1,3-diol, TsOH, 4Å molecule sieves; (c) N-(4-Aminophenyl)maleimide, TiCl4, CH2Cl2.
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