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FKBP8 is normally localized to the outer membrane of the mitochondria. In response to mitochondrial depolarization, FKBP8 preferentially recruits the lipidated form of LC3A to initiate mitophagy. During the process, FKBP8 escapes to the endoplasmic reticulum to avoid being degraded, which is apparently important to prevent apoptosis from occurring during mitophagy.
