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. 2017 Apr 7;18(6):1000–1012. doi: 10.15252/embr.201643560

Figure 2. Loss of the SIR complex suppresses camptothecin hypersensitivity of tof1∆ yeast strains.

Figure 2

  1. Deletion of SIR3 or SIR4 suppresses the camptothecin hypersensitivity of tof1∆ and csm3∆ cells.
  2. Deletion of SIR2 also suppresses camptothecin hypersensitivity of tof1∆ cells and reduces camptothecin sensitivity of a wild‐type strain.
  3. Deletion of SIR2 cannot suppress camptothecin hypersensitivity of a rad51∆ strain.
  4. Inhibition of Sir2 deacetylase activity with sirtinol suppresses camptothecin hypersensitivity of tof1∆ cells.
  5. Mutations that mimic a permanently acetylated H4‐K16 (K16Q) or that remove the binding site for Sir3 (K16G) also suppress camptothecin sensitivity of wild‐type and tof1∆ strains.