Figure EV4. ZBTB48 acts as a transcription factor in contrast to HOT1.

1. Differential expression analysis of the RNA sequencing (RNAseq) gene quantitation, comparing each five WT and ZBTB48 KO clones for U2OS (left) and HeLa (right). Cut‐offs for significant differential expression were set to log₂(fold change) > |1| and −log₁₀(adjusted P‐value) > 2 (FDR < 0.01). These data are analogous to Fig 5A, but without cropping the y‐axis.
2. Differential expression analysis of the RNA sequencing (RNAseq) data comparing each five HeLa WT and HOT1 KO clones. Cut‐offs for significant differential expression were set to log₂(fold change) > |1| and −log₁₀(adjusted P‐value) > 2 (FDR < 0.01).