Figure 7. Inducible genetic deletion of VEGFR2 ameliorates thyroid angiofollicular remodeling during goitrogenesis.

• A
  Diagram showing PTU administration into VEGFR2 ^i∆EC mice.
• B–K
  Images and comparisons of (B–E) expression of VEGFR2 and VEGFR3, (F, G) CD31⁺ BV density, (H, I) fenestrae (arrowheads) and caveolae (arrows), and (J, K) height of thyrocytes in VEGFR2 ^i∆EC (VR2^∆) and their littermate controls (Co) after 3 weeks of PTU administration. All scale bars, 50 μm except scale bars in (B), 500 μm, and scale bars in (H), 0.5 μm.
• L, M
  Gross images and comparisons of thyroid weights after 3 weeks of PTU administration in VEGFR2 ^i∆EC mice compared with Co. Scale bar, 1 mm.

Data information: Each group, n = 4–5. Error bars represent mean ± s.d. Mann–Whitney U‐test was used in (C, E, G, I, K, and M).