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. 2017 Apr 10;9(6):770–785. doi: 10.15252/emmm.201607096

Figure 5. PIKfyve inhibition reduces cardiac hypertrophy and improves cardiac function in vivo .

Figure 5

  • A
    Representative 2D‐M‐Mode echocardiographic images of non‐obese (ND) or obese (HFD) mice treated intraperitoneally with STA or vehicle only (Vehicle).
  • B–E
    Echocardiographic measures of ejection fraction (EF, B), fractional shortening (FS, C), left ventricular posterior wall thickness at end diastole (LVPWd, D) and interventricular septum thickness at end diastole (IVSTd, E) of ND or HFD vehicle‐ or STA‐treated mice.
  • F
    Quantification of the heart weight‐to‐body weight ratio (HW/BW).
  • G
    Quantification of myocyte cross‐sectional area from heart cryosections.
  • H, I
    Expression levels of β‐MHC (H) and BNP (I) were measured by qRT‐PCR from cardiac tissues.
  • J
    Cardiac fibrosis was quantified on heart cryosections stained with Sirius red. Scale bar is 100 μm.
Data information: Data are presented as mean ± SEM. Student's t‐test, *P < 0.05; **P < 0.01 ***P < 0.001 between indicated conditions, n = 4–8 mice per group.