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. 2017 Jul;92(1):88–99. doi: 10.1124/mol.117.108563

Fig. 1.

Fig. 1.

FMP-Red-Dye modulates α1β3γ2 and α4β3δ GABAARs expressed in HEK 293 and L-tk cells, respectively. (A and B) FMP-Red-Dye causes a slow increase in fluorescence [arbitrary florescence units (AFUs)] in cells expressing both receptor types over a 30-minute period that is blocked by 1 µM PTX. The AFU value in GABAAR-null cells minimally changes during the 30 minutes after onset of FMP-Red-Dye exposure. (C and D) GABA (1 µM) causes an instantaneous increase in AFUs in cells expressing both receptors types compared with GABAAR-null cells; the AFU continues to slowly rise over 30 minute. GABA has no effect on AFUs in GABAAR-null cells.