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. 2017 Apr 4;28(6):1388–1398. doi: 10.1093/annonc/mdx076

Figure 1.

Figure 1.

(A) Engagement between programmed death 1 (PD-1) and its ligands, PD-L1 and PD-L2, can enable some tumors to evade T-cell immune surveillance. PD-1 inhibitors such as pembrolizumab can ‘unmask’ PD-L1-expressing cells from the antitumor immune response. (B) Design of the pembrolizumab monoclonal antibody. CDR, complementarity determining region; EC50, half-maximal effective concentration; IC50, half-maximal inhibitory concentration; KD, dissociation constant; MHC-1, major histocompatibility complex 1; PD-1, programmed death 1; PD-L1, programmed death ligand 1; PD-L2, programmed death ligand 2; TCR, T-cell receptor.