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. 2017 Apr 25;9(5):424. doi: 10.3390/nu9050424

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Impact of EPA and DHA on canonical pathways in LPS-stimulated macrophages. The effect of 75, 50 and 10 µ of EPA or DHA on gene regulation in LPS-stimulated macrophages is shown ((a–c), respectively). Differentially expressed genes are organized in canonical pathways regrouped into different families (immune response, apoptosis, cellular cycle, and other pathways). The amount of up- and down-regulated genes within each pathway is also shown (horizontal grey and black bars, respectively). MIF: macrophage migration inhibitory factor, IL: interleukin, TREM: Triggering receptor expressed on myeloid cells 1, ATM: Ataxia telangiectasia Mutated, NFKB: nuclear factor-kappa B, NRF2: Nuclear factor 2, ERK5: Extracellular-signal-regulated kinase 5, RXR: Retinoid X receptor, LXR: Liver X receptor.

Impact of EPA and DHA on canonical pathways in LPS-stimulated macrophages. The effect of 75, 50 and 10 µ of EPA or DHA on gene regulation in LPS-stimulated macrophages is shown ((a–c), respectively). Differentially expressed genes are organized in canonical pathways regrouped into different families (immune response, apoptosis, cellular cycle, and other pathways). The amount of up- and down-regulated genes within each pathway is also shown (horizontal grey and black bars, respectively). MIF: macrophage migration inhibitory factor, IL: interleukin, TREM: Triggering receptor expressed on myeloid cells 1, ATM: Ataxia telangiectasia Mutated, NFKB: nuclear factor-kappa B, NRF2: Nuclear factor 2, ERK5: Extracellular-signal-regulated kinase 5, RXR: Retinoid X receptor, LXR: Liver X receptor.