. 2017 May 9;9(5):472. doi: 10.3390/nu9050472

Table 2.

Study characteristics.

Species	Tissue	Platform	Number of Probes	Dietary Intervention	References
Human studies
Ex vivo	Adipose tissue	GeneChip arrays Affymetrix	17,699	MUFA vs. SFA	[20]
Ex vivo	PBMC	PrimeView ™ arrays Affymetrix	36,000	Med diet vs. previous diet	[21]
Ex vivo	PBMC	GeneChip arrays Affymetrix	17,699	MUFA vs. SFA vs. Med diet	[22]
Ex vivo	PBMC	Oligo Microarrays (G4112A) Agilent	45,220	Phenolic compounds, postprandial	[23]
Ex vivo	PBMC	HT-12 v4 Illumina V2 MicroRNA Illumina	47,000	Phenolic compounds, postprandial	[24]
Ex vivo	PBMC	HT-12 v4 Illumina V2 MicroRNA Illumina	1146	Phenolic compounds, postprandial	[24]
Ex vivo	PBMC	Gene 1.1 ST Array Affymetrix	56,249	MUFA vs. SFA, postprandial	[25]
Ex vivo	PBMC	Genome Survey Microarray V2.0 Applied Biosystems	32,878	Virgin olive oil, postprandial	[26]
Ex vivo	PBMC	GeneChip U133A 2.0 Affymetrix	18,400	Low fat vs. Med diet	[27]
Ex vivo	PBMC	Genome Survey Microarray V2.0 Applied Biosystems	32,878	Long-term virgin olive oil consumption	[28]
Ex vivo	PBMC	HT-12 v4 BeadChip Illumina	47,000	OO vs. EPA or DHA	[29]
Cells of human origin
In vitro	Colon cancer cells	Custom-made Oligo Microarray chip	700	Phenolic compounds	[30]
In vitro	Erythroleukemic cell line K562 and keratinocytes	RNA seq	20 × 10⁶ reads	Hydroxytyrosol	[15,16]
In vitro	JIMT1 breast cancer cells	Oligo Microarrays (G4112F) Agilent	45,220	Phenolic compounds	[31,32]
In vitro	Mesenchymal stem cells	Serial Analysis of Gene Expression	Counts not shown	Oleuropein	[19]
In vitro	Prostatic tumors	Human genome 133A 2.0 Affymetrix	22,000	Fish oil vs. OO or corn oil	[33]
In vitro	SMC	Low density array	4376	TRL from MUFA vs. SFA vs. Med diet	[34]
Animal studies
C. elegans	Whole organism	C. elegans Gene-Chip ^® Genome Arrays Affymetrix	22,500	Tyrosol (250 µM)	[35]
Flounder	Liver	Chip Array Tokyo University	14,461	OO vs. LO	[36]
Mouse	Adipose tissue	MouseRef-8 v2 Illumina	25,600	Hydroxytyrosol (0.03%)	[37]
Mouse	Cerebral cortex Cerebelum	Agilent Mouse GE 44K v2 and Agilent mice miRNA array	39,430	Phenolic content of OO	[38]
Mouse	Cerebral cortex Cerebelum	Agilent Mouse GE 44K v2 and Agilent mice miRNA array	1247	Phenolic content of OO	[38]
Mouse	Intestine	GeneChip MOE430 2 Affymetrix	39,000	OO vs. palm or safflower	[39]
Mouse	Liver	GeneChip MOE430A Affymetrix	22,690	Unsaponifiable fraction of OO	[40]
Mouse	Liver	GeneChip MOE430A Affymetrix	22,690	Oleanolic acid	[41]
Mouse	Liver	GeneChip MOE430A Affymetrix	22,690	Maslinic acid	[42]
Mouse	Liver	RNA seq	23 × 10⁶ reads	OO vs. Western or Long-chain MUFA	[17]
Rat	Colon	Codelink UniSetRat I GE Healthcare	9028	Fish oil vs. OO or corn oil	[43,44]
Rat	Liver	Array Affymetrix	12,500	Fish oil vs. OO	[45]
Rat	Liver	Rat U34 Affymetrix	26,334	MUFA vs. SFA, long-term	[46]
Rat	Liver	Expression Array 230 version 2.0 Affymetrix	31,000	Virgin olive oil, fasting vs. postprandial	[47]
Rat	Liver	RGU34A GeneChip Affymetrix	8800	OO vs. corn oil, long-term regimen	[48]
Rat	Mammary glands	RNA seq	Counts not shown	OO vs butter or safflower	[18]
Rat	Mammary tumors	Expression Array 230 2.0 Affymetrix	31,000	Hydroxytyrosol	[49]
Rat	Mammary tumors	Rat Exon 1.0 ST Array Affymetrix	1 × 10⁶	OO vs. corn and low fat diets	[50]
Swine	Muscle	Porcine genome array Affymetrix	23,937	OO vs. beef tallow, coconut or soybean oils	[51]

DHA: docosahexaenoic acid; EPA: eicosapentaenoic acid; LO: linseed oil; Med: Mediterranean; MUFA: monounsaturated fatty acids; OO: olive oil; PBMC: peripheral blood mononuclear cells; SFA: saturated fatty acids; SMC: smooth muscle cells; TRL: triglyceride-rich lipoproteins.