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. 2017 Jun 1;10:19. doi: 10.1186/s13041-017-0301-3

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Human Alzheimer’s disease hippocampus has lower BDNF levels. a Immunoblot showing BDNF expression in the hippocampus of four AD and four age matched controls (AC). In AD hippocampus the prepro-BDNF levels were significantly lower than AC hippocampus (AC: 1.8 ± 0.14, n = 7; AD: 1.25 ± 0.11, n = 6. P = 0.012) b and negatively correlated with the Braak stage c. Pro-BDNF expression were also lower in AD hippocampus (AC: 0.81 ± 0.07, n = 7; AD: 0.49 ± 0.073, n = 6. P = 0.0073) d, e. Data are represented as mean ± SE (Student’s t-test, *P < 0.05 and **P < 0.005)