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. 2017 May 31;18:10. doi: 10.1186/s12858-017-0083-3

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — RR601 inhibits PTP1B and SHP-2. PTP1B and SHP-2 initial velocities versus RR601 concentration were fit to Eq. (1) resulting in estimated RR601 IC₅₀ ± SE values of 2.1 ± 0.2 for PTP1B and 1.1 ± 0.1 μM for SHP-2. Activity was monitored utilizing pNPP as the substrate. Data points represent the mean ± SD of three or four trials with three to eight wells at each RR601 concentration