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. 2017 May 31;19:114. doi: 10.1186/s13075-017-1325-x

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Timeline depicting the induction of arthritis in rats and thereupon methotrexate (MTX) interventions. On day 7 and day 14 the first and second immunization (Im1 and Im2) was administered, on day 19 the delayed type hypersensitivity (DTH) test and thereupon four intra-articular (i.a.) injections were administered. Upon arthritic induction the rats were administered saline (black arrows) or 2× MTX (dark grey arrows) or 4× MTX (light grey arrows). PET-CT (#) was performed before (day 22) and after (day 40) MTX therapy. At the end of the study (day 40), ex-vivo tissue distribution (TD) was performed. Healthy rats did not receive any arthritic induction or MTX treatment and were sacrificed on day 40