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. 2017 May 31;19:114. doi: 10.1186/s13075-017-1325-x

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Representative coronal PET-CT scans of [¹⁸F]fluoro-PEG-folate in control and arthritic rats. a Control (before therapy, day 22); b 2× MTX and c 4× MTX (after therapy, day 40). Orange ellipsoid: ROI drawn around the synovium of the knee joint. Arthritic (right) and contralateral knees (left) depicted on each image. Standardized uptake value (SUV) scale bar from minimum 0 to maximum 1, represent the uptake of the tracer. TACs of [¹⁸F]fluoro-PEG-folate uptake are expressed as SUV (±SD) in arthritic and contralateral knees of the control group (d), 2 × -MTX group (e) and 4 × -MTX group (f)