Table 8.
Relationship between BRCA1/2 methylation and clinicopathological variables in BRCA2-related carcinomas
| BRCA2-related carcinomas | Grades 1–2 vs. 3 | Ductal vs. lobular tumors | ER-positive vs. ER-negative | PR-positive vs. PR-negative | HER2-positive vs. HER2-negative | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Probe | Test statistica | p Value | Test statistica | p Value | Test statistica | p Value | Test statistica | p Value | Test statistica | p Value |
| BRCA1.1 | 1.065b | 0.542 | 0.147b | 1.000 | 0.769b | 0.432 | 0.002b | 1.000 | 0.067b | 1.000 |
| BRCA1.2 | 0.062b | 1.000 | 0.057b | 1.000 | 0.248b | 0.695 | 0.730c | 0.491 | 0.760b | 1.000 |
| BRCA1.3 | 1.065b | 0.542 | 0.147b | 1.000 | 0.769b | 0.432 | 0.002b | 1.000 | 0.067b | 1.000 |
| BRCA1 totalc | 0.062b | 1.000 | 0.057b | 1.000 | 0.248b | 0.695 | 0.730bb | 0.491 | 0.760b | 1.000 |
| BRCA2.1 | 2.200c | 0.266 | 0.002b | 1.000 | 0.088b | 1.000 | 2.528c | 0.166 | 1.238b | 0.455 |
| BRCA2.2 | 1.650b | 0.534 | 0.229b | 1.000 | 0.149b | 1.000 | 0.437b | 0.601 | 0.103b | 1.000 |
| BRCA2.3 | 3.039b | 0.136 | 0.115b | 1.000 | 1.742b | 0.238 | 0.022c | 1.000 | 0.760b | 1.000 |
| BRCA2.4 | 0.569b | 0.586 | 0.317b | 1.000 | 0.001b | 1.000 | 0.004b | 1.000 | 0.142b | 1.000 |
| BRCA2 totalc | 3.110b | 0.132 | 0.057b | 1.000 | 0.916b | 0.431 | 0.863c | 0.481 | 1.587b | 0.394 |
Abbreviations: BRCA1/2 BRCA1 and BRCA2, ER Estrogen receptor, ER Estrogen receptor, HER2 Human epidermal growth factor receptor 2, PR Progesterone receptor
aPearson’s chi-square test or Fisher’s exact test
cPearson’s chi-square test
bFisher’s exact test