. Author manuscript; available in PMC: 2017 Jun 1.

Published in final edited form as: Birth Defects Res A Clin Mol Teratol. 2008 Jun;82(6):453–463. doi: 10.1002/bdra.20457

Table 3.

Effect of oxidative stress and antioxidant treatment on embryonic CNC cell migration

Treatment	Pax3^LacZ/+		Pax3^GFP/+
Treatment	normal	CNC defect	normal	CNC defect
PG	19	1	12	0
AA	1	28^a	1	11^a
AA + GSH-EE	16	5^b	10	6^c
AA + Vit E	15	2 ^b	13	3^c

Pax3^LacZ/+ or Pax3^GFP/+ embryos from control propylene glycol- (PG) or antimycin A- (AA) injected pregnancies were obtained on day 9.5 and examined for CNC migration defects. Antioxidants (GSH-EE or vitamin E succinate) were administered as in Table 2.

p < 0.0001 vs. PG

p < 0.0001 vs. AA; NS vs. PG

p = 0.003 vs. AA; NS vs. PG