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. 2017 May 31;9:44. doi: 10.1186/s13098-017-0242-0

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Mean weight loss and categorical weight loss in the COR-II trial. a Percent weight loss (observed; LS mean ± SE) by visit in the week 28 and 56 completers (NB32 data are weighted for weeks 32–56), and percent weight loss for the week 28 and 56 mITT-LOCF subjects. b Categorical weight loss in week 28 and 56 mITT-LOCF and completers. ***P < 0.001 for NB32 vs. placebo. mITT analysis: prespecified modified intent-to-treat population composed of all randomized participants with a baseline weight and ≥1 post-baseline weight on study drug (+1 day post-last dose); LOCF: missing data were imputed by carrying forward the last observation on study drug; completers: participants who completed 28 or 56 weeks of treatment

Adapted from Apovian et al. [62]