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Metabolism of oprozomib by HLMs and recombinant P450s. (A) Percentage of oprozomib remaining in pooled HLMs in the presence or absence of cofactor NADPH. Initial oprozomib concentration was 1 µM. (B) P450 phenotyping on oprozomib oxidation using six major P450 isoforms. Oprozomib was incubated with six recombinant P450 isoforms for various incubation times, individually. The loss of oprozomib was quantified using LC-MS/MS assays. Data represent mean ± S.D. from triplicate incubations.
