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. 2017 Mar 31;13(6):4238–4244. doi: 10.3892/ol.2017.5962

Figure 1.

Figure 1.

Effect of IL-17A on the proliferation of nasopharyngeal carcinoma C666-1 cells. (A) C666-1 cells were treated with various doses (0.001–100 ng/ml) of human IL-17A to induce cellular proliferation for 48 h. CCK-8 analysis revealed that IL-17A stimulation enhanced the proliferation of C666-1 cells in a dose-dependent manner in vitro. **P<0.01 vs. untreated control group. (B) C666-1 cells were incubated with various doses of anti-IL-17AR neutralizing antibody or isotype control IgG for 30 min, and subsequently cellular proliferation was induced by 10 ng/ml IL-17A for 48 h. CCK-8 analysis demonstrated that blockade of the IL-17A receptor suppressed the IL-17A-triggered proliferation of C666-1 cells in a dose-dependent manner. *P<0.05, **P<0.01 vs. IgG+IL-17A group. The data are representative of three independent experiments. All results are represented as the mean ± standard deviation. IL-17A, interleukin-17A; CCK-8, Cell Counting Kit-8; OD, optical density; IgG, immunoglobulin G.