Table II.

Univariate and multivariate survival analyses of clinicopathological variables for 263 gastric carcinoma patients.

A, Model without IGFBP6 expression
	Univariate analysis			Multivariate analysis
Variables	HR	95% CI	P-value	HR	95% CI	P-value
Gender (male vs. female)	1.513	0.994–2.303	0.054
Age, years (≥60 vs. <60)	1.674	1.120–2.504	0.012a	1.437	0.953–2.166	0.083
Location (distal/proximal/total)	0.475	0.311–0.725	0.001a	0.574	0.375–0.878	0.010a
Size, cm (>5 vs. ≤5)	2.392	1.595–3.588	<0.001a	1.985	1.302–3.025	0.001a
Histological grade (G3 vs. G2/G1)	2.549	1.420–4.577	0.002a	2.142	1.186–3.867	0.012a
Radical resection (no vs. yes)	4.288	2.694–6.824	<0.001a	1.139	0.454–2.859	0.781
T (T4/T3 vs. T2/T1)	5.812	2.359–14.317	<0.001a	3.130	1.217–8.047	0.018a
N (yes vs. no)	4.095	2.123–7.899	<0.001a	3.940	2.002–7.753	<0.001a
M (M1 vs. M0)	5.218	3.145–8.656	<0.001a	3.887	1.432–10.554	0.008a
B, Model containing IGFBP6 expression
	Univariate analysis			Multivariate analysis
Variables	HR	95% CI	P-value	HR	95% CI	P-value
Gender (male vs. female)	1.513	0.994–2.303	0.054
Age, years (≥60 vs. <60)	1.674	1.120–2.504	0.012a	1.457	0.965–2.198	0.073
Location (distal/proximal/total)	0.475	0.311–0.725	0.001a	0.562	0.367–0.860	0.008a
Size, cm (>5 vs. ≤5)	2.392	1.595–3.588	<0.001a	1.795	1.170–2.753	0.007a
Histological grade (G3 vs. G2/G1)	2.549	1.420–4.577	0.002a	1.819	0.996–3.321	0.052
Radical resection (no vs. yes)	4.288	2.694–6.824	<0.001a	1.023	0.407–2.574	0.961
IGFBP-6 expression (low vs. high)	3.949	2.237–6.971	<0.001a	2.104	1.162–3.807	0.014a
T (T4/T3 vs. T2/T1)	5.812	2.359–14.317	<0.001a	2.637	1.018–6.831	0.046a
N (yes vs. no)	4.095	2.123–7.899	<0.001a	3.772	1.914–7.435	<0.001a
M (M1 vs. M0)	5.218	3.145–8.656	<0.001a	4.359	1.600–11.876	0.004a

^aP<0.05. T, tumor; N, node; M, metastasis; IGFBP-6, insulin-like growth factor binding protein 6.