Figure 2.

SIRP-α negatively regulates CaP cellular proliferation by enhancing cell apoptosis. Cells were transfected with VT, KD and OV. (A) Efficiency of transfection was examined in LNCaP and LNCaP-A. Growth curves for (B) LNCaP and (C) LNCaP-A were determined, and apoptosis rates for (D) LNCaP and (E) LNCaP-A were determined. Apoptosis marker expression for (F) LNCaP and (G) LNCaP-A were determined. Error bars represent the standard deviation. **P<0.01. SIRP, signal regulatory protein; OV, pcDNA3.1-SIRP-α; VT, control vector; KD, shRNA for SIRP-α; Bax, Bcl associated X.