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Increased cytokine production of SIRP-α knockdown in CaP cells. Cells were transfected with VT, KD and OV, and cytokine production was determined using ELISA kits. (A) TNFα, (B) IL-6, (C) NO, (D) CXCL2, (E) CCL3, (F) CCL5. SIRP, signal regulatory protein; CaP, prostate cancer; VT, control vector; KD, shRNA for SIRP-α; OV, pcDNA3.1-SIRP-α; TNF, tumor necrosis factor; IL-6, interleukin-6; NO, nitric oxide; CXCL2, chemokine (C-X-C motif) ligand 2; CCL, CC chemokine ligand.
