Figure 5.

SIRP-α knockdown decreases cell apoptosis by enhancing COX-2 expression. (A) Cells were transfected with KD, and COX-2 expression were determined by western blotting. VT and GADPH were used as controls. (B) Cells were co-transfected with si-COX-2 and KD and then the apoptosis rate and apoptosis marker were determined. Error bars represent the standard deviation. **P<0.01; ***P<0.001. SIRP, signal regulatory protein; COX-2, cyclooxygenase-2; KD, shRNA-SIRP-α; VT, vector control; si-, small interfering RNA; Bax, Bcl associated X.