Table 2. Inhibition of tubulin polymerization in vitro.
Compounds | IC50 |
---|---|
Colchicinea | 2.86 ± 0.16μM |
Vinblastinea | 1.57 ± 0.34μM |
Latrunculin Bb | >1 mM |
Cucurbitacin B | >1 mM |
Cucurbitacin E | 566.91 ± 113.5μM |
Cucurbitacin I | >1 mM |
Notes.
Active on tubulin/microtubules.
Active against actin filaments; data are presented as mean ± SD.