Table III.
Selected single-nucleotide polymorphisms and detailed information on the corresponding base and amino acid exchanges as well as MAF.
| Gene | Codon | Exchange, base (amino acid) | MAF (%)a |
|---|---|---|---|
| APEX1 | 148 | T→G (Asp/Glu) | 44.0 |
| MUTYH | 335 | G→C (Gln/His) | 31.9 |
| OGG1 | 326 | C→G (Ser/Cys) | 29.9 |
| PARP1 | 762 | T→C (Val/Ala) | 24.4 |
| PARP4 | 1,280 | G→C (Gly/Arg) | 45.8 |
| 1,328 | C→A (Pro/Thr) | 45.8 | |
| XRCC1 | 194 | C→T (Arg/Trp) | 13.1 |
| 399 | G→A (Arg/Gln) | 26.6 |
a
According to http://www.ncbi.nlm.nih.gov/snp/. MAF, minor allele frequency; APEX1, apurinic/apyrimidinic endonuclease 1; MUTYH, mutY DNA glycosylase, earlier mutY homolog (E. coli); OGG1, 8-oxoguanine DNA glycosylase 1; PARP, poly (ADP-ribose) polymerase; XRCC1, X-ray repair cross-complementing 1.