Table I.
IC50 and RI values of H446 and H446/EP cell lines.
| IC50 (mean ± SD) | |||
|---|---|---|---|
| Drug | H446 | H446/EP | RI |
| VP16 | 0.35±0.15 | 19.25±1.49a | 55 |
| DDP | 0.52±0.29 | 14.56±1.35a | 28 |
| EPI | 0.65±0.34 | 5.32±0.27 | 8.18 |
| TAX | 0.11±0.43 | 0.57±0.60 | 5.18 |
| NVB | 3.39±1.35 | 7.32±1.84 | 2.16 |
| CPT-11 | 21.43±2.45 | 98.87±6.95 | 4.61 |
VP16, etoposide; DDP, cisplatin; EPI, epirubicin; TAX, paclitexal; NVB, vinorelbine; CPT-11, irinotecan. Data were represented as mean ± SD of three independent experiments.
a
P<0.01 vs. H446 cell lines. SD, standard deviation; RI, resistance indices.