Table I.

Kyoto Encyclopedia of Genes and Genomes pathway enrichment categories for genes differentially expressed in LLC1 cells following single dose (2 or 10 Gy) or fractionated dose (5×2 Gy) irradiation.

	2 Gy		10 Gy		5×2 Gy
Category	No. of genes	P-value	No. of genes	P-value	No. of genes	P-value
Pathways in cancer	11	0.0005	38	1.76×10−16	53	3.50×10−27
Cell cycle	5	0.0069	25	2.88×10−16	28	3.48×10−18
p53 signaling pathway	10	2.37×10−09	15	2.07×10−10	24	2.46×10−20
MAPK signaling pathway	0	NS	20	2.73×10−06	29	8.91×10−11
Cytokine-cytokine receptor interaction	7	0.0066	19	2.84×10−06	26	1.35×10−09
DNA replication	0	NS	8	2.09×10−06	10	3.89×10−08
TGF-β signaling pathway	3	NS	14	1.92×10−08	14	6.72×10−08
Apoptosis	6	0.0007	16	3.41×10−10	17	1.40×10−10
VEGF signaling pathway	0	NS	9	7.35×10−05	12	8.71×10−07
Hepatitis C	0	NS	16	1.63×10−07	19	4.13×10−09
Mismatch repair	0	NS	7	1.10×10−06	8	1.20×10−07
Nucleotide excision repair	0	NS	7	7.45×10−05	12	1.72×10−09
Wnt signaling pathway	0	NS	9	0.0076	15	1.24×10−05
Chemokine signaling pathway	0	NS	15	2.07×10−05	16	2.50×10−05
B cell receptor signaling pathway	5	0.0022	11	1.96×10−06	10	3.51×10−05
Base excision repair	2	NS	8	3.42×10−06	7	7.77×10−05
Jak-STAT signaling pathway	6	0.0035	14	1.13×10−05	14	4.64×10−05
Insulin signaling pathway	4	NS	17	2.63×10−08	17	1.20×10−07
RIG-I-like receptor signaling pathway	0	NS	2	NS	6	0.01
Toll-like receptor signaling pathway	0	NS	7	0.008	9	0.0013
Homologous recombination	0	NS	5	0.0006	5	0.0009

No significance; MAPK, mitogen activated protein kinase; TGF, transforming growth factor; VEGF, vascular endothelial growth factor; Wnt, wingless-type MMTV integration site family; Jak, Janus kinase; STAT, signal transducer and activator of transcription.