Figure 7.

miR-217 negatively regulated KRAS expression at the post-transcriptional level. (A) No differences were found in KRAS mRNA levels between human leukemia HL-60 and K562 cells transfected with miR-217 and NC. Data are presented as mean ± standard deviation. (B) Human leukemia HL-60 and K562 cells transfected with miR-217 showed a decreased KRAS expression at protein level compared with cells transfected with NC. Data are presented as mean ± standard deviation. β-actin was used as a control in the western blot analysis. *P<0.05 compared with their respective controls. KRAS, Kirsten rat sarcoma viral oncogene homolog; miR, microRNA; NC, normal control.